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Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

26.05.2025
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My guest is Dr. Melissa Ilardo, Ph.D., professor of biomedical informatics at the University of Utah. We discuss the interplay between genes and behaviors, including how certain behaviors can improve resilience by changing gene and organ function, as well as natural selection events happening in humans today.

We also discuss the immune system–related reasons people find the smells of potential mates attractive—or not.

We explore how physical and psychological traits are passed from one generation to the next, and the specific behaviors that can influence gene expression to improve health and performance.

Melissa explains her lab’s pioneering research on breath-hold training and how activation of the dive reflex through breath holding can significantly improve oxygen availability by changing spleen size and function.

We also delve into the medical uses and ethics of gene editing to cure disease in both babies and adults.

For those interested in genes and inheritance, human performance, immune system function, and natural selection, this episode illustrates the remarkable interplay between human nature and nurture.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

AG1: https://drinkag1.com/huberman

Joovv: https://joovv.com/huberman

Eight Sleep: https://eightsleep.com/huberman

LMNT: https://drinklmnt.com/huberman

Function: https://functionhealth.com/huberman

Timestamps

Melissa Ilardo

Nature vs Nurture, Gene Expression, Eye Color

Sponsors: Joovv & Eight Sleep

Epigenetics, Trauma, Mutations; Hybrid Vigor, Mate Attraction

Globalization; Homo Sapiens, Mating & Evolution; Mutations

Sea Nomads, Bajau & Moken Groups; Free Diving, Dangers & Gasp Reflex

Cultural Traditions, Free Diving & Families; Fishing

Mammalian Dive Reflex, Oxygen, Spleen, Cold Water & Face; Exercise

Sponsors: AG1 & LMNT

Free Diving, Spleen, Thyroid Hormone, Performance Enhancement

Dive Reflex, Immune System; Swimming & Health; Coastal Regions & Genetics

Female Free Divers, Haenyeo, Cold Water, Age, Protein

Human Evolution & Diet, Lactase, Fat

Korean Female Free Divers & Adaptations, Cardiovascular, Pregnancy

Miscarriages & Genetic Selection; Bajau, External Appearance, Mate Selection

Sponsor: Function

Free Diving, Underwater Vision; Super-Performers & Genetics

Cognitive Performance, Autism, Creativity; Genetic Determinism & Mindset

Genetics & Ethics, CRISPR, Embryo Genetic Screening

Admixture, Genetics; Are Humans a Single Species?

Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

Disclaimer & Disclosures

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Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo
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